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The Suzuki cross‐coupling reaction in pure water catalyzed by ligandless palladium using polyethylene glycol derivatives as surfactant
Author(s) -
Xiang Liu,
Xiaohua Zhao,
Ming Lu
Publication year - 2013
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3018
Subject(s) - phenylboronic acid , chemistry , polyethylene glycol , aryl , palladium , pulmonary surfactant , catalysis , halide , coupling reaction , polymer chemistry , peg ratio , organic chemistry , biochemistry , alkyl , finance , economics
The results of a ligandless Pd(OAc) 2 ‐catalyzed Suzuki–Miyaura coupling experiment are presented. It was found that the use of polyethylene glycol phosphonium salts (PEG‐quat) as surfactant resulted in very rapid reactions of aryl halides with phenylboronic acids in pure water. Moreover, aryl chlorides such as 4‐nitrochlorobenezene reacted quantitatively with phenylboronic acid under optimized conditions. Copyright © 2013 John Wiley & Sons, Ltd.