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Novel microwave synthesis of half‐sandwich [(η 6 ‐C 6 H 6 )Ru] complexes and an evaluation of the biological activity and biochemical reactivity
Author(s) -
Beckford Floyd A.,
Stott Alyssa,
GonzalezSarrías Antonio,
Seeram Navindra P.
Publication year - 2013
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.3007
Subject(s) - chemistry , semicarbazone , ruthenium , reactivity (psychology) , binding constant , in vitro , stereochemistry , human serum albumin , combinatorial chemistry , nuclear chemistry , medicinal chemistry , binding site , organic chemistry , biochemistry , catalysis , medicine , alternative medicine , pathology
We have used a novel microwave‐assisted method to synthesize a pair of half‐sandwich ruthenium–arene–thiosemicarbazone complexes of the type [(η 6 ‐C 6 H 6 Ru(TSC)Cl]PF 6 . The thiosemicarbazone (TSC) ligands are 2‐(anthracen‐9‐ylmethylene)hydrazinecarbothioamide and 2‐(anthracen‐9‐ylmethylene)‐ N ‐ethylhydrazinecarbothioamide derived from 9‐anthraldehyde. The complexes are moderately strong binders of DNA, with binding constants of 10 4 m −1 . They are also strong binders of human serum albumin, having binding constants of the order of 10 5 m −1 . The complexes show some in vitro anticancer activity against human colon cancer cells, Caco‐2 and HCT‐116, with positive therapeutic indices. They did not show any activity as antibacterial agents against the organisms that were studied. Copyright © 2013 John Wiley & Sons, Ltd.