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CuI/amino acid‐catalyzed coupling and cyclization of β‐bromo‐α,β‐unsaturated amides with terminal alkynes leading to (3 Z )‐3‐alkylidenepyrrol‐1‐ones
Author(s) -
Son Jong Ik,
Cho Chan Sik,
Choi HeungJin
Publication year - 2013
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.2990
Subject(s) - chemistry , catalysis , terminal (telecommunication) , base (topology) , coupling (piping) , stereochemistry , amino acid , medicinal chemistry , organic chemistry , biochemistry , mechanical engineering , mathematical analysis , telecommunications , mathematics , computer science , engineering
β‐Bromo‐α,β‐unsaturated amides are coupled and cyclized with terminal alkynes in DMF at 110 °C in the presence of a catalytic amount of CuI and amino acid along with a base to give the corresponding (3 Z )‐3‐alkylidenepyrrol‐1‐ones in moderate to good yields. Copyright © 2013 John Wiley & Sons, Ltd.

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