Protecting‐group‐free palladium‐catalyzed  hydroxylation , C–O and C–N coupling of chiral 6‐bromo‐ and 6,6’‐dibromo‐ 1,1’‐binaphthols | Zendy

Dong Junyu | Zendy; Li Tianbin | Zendy; Dai Chuan | Zendy; Weng Wen | Zendy; Xue Xinghua | Zendy; Zhang Yuyu | Zendy; Zeng Qingle | Zendy

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Protecting‐group‐free palladium‐catalyzed hydroxylation , C–O and C–N coupling of chiral 6‐bromo‐ and 6,6’‐dibromo‐ 1,1’‐binaphthols

Author(s) -

Dong Junyu,

Li Tianbin,

Dai Chuan,

Weng Wen,

Xue Xinghua,

Zhang Yuyu,

Zeng Qingle

Publication year - 2013

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.2982

Subject(s) - chemistry , palladium , hydroxylation , protecting group , catalysis , combinatorial chemistry , group (periodic table) , functional group , stereochemistry , organic chemistry , enzyme , alkyl , polymer

A straightforward, protecting‐group‐free protocol for the synthesis of chiral 6‐substituted and 6,6’‐disubstituted binols (binol = 1,1’‐bi‐2‐naphthol) by palladium‐catalyzed hydroxylation , C–N and C–O coupling of chiral 6‐bromo‐ and 6,6’ ‐dibromo‐1,1’‐binaphthols is developed. The protecting group free palladium‐catalyzed hydroxylation , C–O and C–N cross‐coupling protocol affords a straightforward and general method for the synthesis of chiral 6‐substituted and 6,6’‐disubstituted binols with good yields, avoiding the tedious procedures of introduction and removal of protecting groups . Copyright © 2013 John Wiley & Sons, Ltd.

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