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CuI/amino acid catalysis in coupling and cyclization of β‐bromo‐α,β‐unsaturated carboxylic acids with terminal alkynes leading to alkylidenefuranones
Author(s) -
Ho Son Long,
Cho Chan Sik,
Choi HeungJin,
Sohn HoSang
Publication year - 2013
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.2963
Subject(s) - chemistry , catalysis , carboxylic acid , terminal (telecommunication) , microwave irradiation , amino acid , organic chemistry , medicinal chemistry , biochemistry , telecommunications , computer science
β‐Bromo‐α,β‐unsaturated carboxylic acids are coupled and cyclized with terminal alkynes in DMF at 110°C in the presence of a catalytic amount of CuI and amino acid along with a base to give alkylidenefuranones in good yields. Similar reaction under microwave irradiation also gave alkylidenefuranones in higher yields. Copyright © 2013 John Wiley & Sons, Ltd.

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