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Binuclear meta ‐xylyl‐linked Ag(I)‐ N ‐heterocyclic carbene complexes of N ‐alkyl/aryl‐alkyl‐substituted bis‐benzimidazolium salts: synthesis, crystal structures and in vitro anticancer studies
Author(s) -
Haque Rosenani A.,
Iqbal Muhammad Adnan,
Budagumpi Srinivasa,
Khadeer Ahamed Mohamed B.,
Abdul Majid Amin M. S.,
Hasanudin Noorhafizah
Publication year - 2013
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.2953
Subject(s) - carbene , chemistry , aryl , hexafluorophosphate , steric effects , counterion , alkyl , tetrafluoroborate , medicinal chemistry , stereochemistry , ligand (biochemistry) , crystal structure , organic chemistry , catalysis , ion , ionic liquid , biochemistry , receptor
Salts of meta ‐xylyl‐linked N ‐ethyl/ n ‐butyl/benzyl‐substituted bis‐benzimidazolium having hexafluorophosphate counterions have been synthesized. The corresponding binuclear Ag(I)‐ N ‐heterocyclic carbene complexes were prepared by the reaction of Ag 2 O. The N ‐heterocyclic carbene (NHC) ligand precursor 7 and Ag(I)–NHC complexes 10 and 11 have been structurally characterized by single‐crystal X‐ray diffraction technique. All of the reported compounds have been tested for their anticancer activity using human colorectal (HCT 116) cancer cell lines. Sterically varied benzimidazolium salts displayed significant activity against HCT 116 cell line, yielding IC 50 values in the range 0.1–19.4 µ m , while Ag(I)–carbene complexes showed exceptionally good activity (0.2–1.3 µ m ) against tested cancer cell lines. Copyright © 2013 John Wiley & Sons, Ltd.