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Bifunctional Schiff base/Ti(IV) catalysts for enantioselective cyanoformylation of aldehydes with ethyl cyanoformate
Author(s) -
Ji Nan,
Yao Lin,
He Wei,
Li Yurong
Publication year - 2013
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.2951
Subject(s) - chemistry , bifunctional , enantioselective synthesis , cyanohydrin , schiff base , catalysis , enantiomeric excess , organic chemistry , bifunctional catalyst , enantiomer , polymer chemistry
A new bifunctional titanium/Schiff base catalyst was developed for the enantioselective cyanoformylation of aldehydes with ethyl cyanoformate. The reaction proceeded smoothly with a mild reaction condition to afford the cyanohydrin ethyl carbonates in high yields (up to 96%) and good enantioselectivities (up to 85% enantiomeric excess). Copyright © 2013 John Wiley & Sons, Ltd.