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Ligand‐ and solvent‐free synthesis of 2‐aminobenzothiazoles by copper‐catalyzed tandem reaction of 2‐haloanilines with isothiocyanates
Author(s) -
Yao Ruiya,
Liu Haiyi,
Wu Yichao,
Cai Mingzhong
Publication year - 2013
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.2949
Subject(s) - chemistry , tandem , economic shortage , ligand (biochemistry) , combinatorial chemistry , copper , catalysis , solvent , cascade reaction , environmentally friendly , organic chemistry , ecology , linguistics , philosophy , materials science , receptor , biochemistry , government (linguistics) , composite material , biology
We report an environmentally friendly, efficient and practical method for the synthesis of 2‐aminobenzothiazoles by a copper(II)‐catalyzed tandem reaction of 2‐haloanilines with isothiocyanates under ligand‐ and solvent‐free conditions in air. The developed methodology conforms to the principles of 'green chemistry' and addresses the shortage of such methods for the synthesis of 2‐aminobenzothiazoles. The reaction is quite general and generates a variety of 2‐aminobenzothiazoles in good to excellent yields. Copyright © 2012 John Wiley & Sons, Ltd.

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