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Palladium‐catalyzed synthesis of 8‐allyl or 8‐prenylcoumarins by using organotin reagents as multicoupling nucleophiles
Author(s) -
Yin Qiang,
Yan Han,
Zhang Yaqin,
Wang Yige,
Zhang Guojin,
He Yuxiang,
Zhang Weihua
Publication year - 2013
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.2944
Subject(s) - chemistry , stille reaction , catalysis , palladium , nucleophile , reagent , coupling reaction , reaction conditions , organic chemistry , medicinal chemistry , combinatorial chemistry
In this study, 8‐iodocoumarin derivatives underwent a direct Stille cross‐coupling reaction with several organotin compounds in the presence of a catalytic amount of Pd(PPh 3 ) 4 in DMF at 80 °C. The cross‐coupling reaction proceeded smoothly under mild conditions and permitted the formation of 8‐allyl or 8‐prenylcoumarin compounds in good yields. Copyright © 2012 John Wiley & Sons, Ltd.