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Fe 3 O 4 nanoparticle‐supported copper(I): magnetically recoverable and reusable catalyst for the synthesis of quinazolinones and bicyclic pyrimidinones
Author(s) -
Yu Lin,
Wang Min,
Li Pinhua,
Wang Lei
Publication year - 2012
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.2902
Subject(s) - pyrimidinones , chemistry , catalysis , bicyclic molecule , copper , nanoparticle , combinatorial chemistry , organic chemistry , medicinal chemistry , nuclear chemistry , nanotechnology , materials science
A highly efficient, easily recoverable and reusable Fe 3 O 4 magnetic nanoparticle‐supported Cu(I) catalyst has been developed for the synthesis of quinazolinones and bicyclic pyrimidinones. In the presence of supported Cu(I) catalyst (10 mol%), amidines reacted with substituted 2‐halobenzoic acids and 2‐bromocycloalk‐1‐enecarboxylic acids to generate the corresponding N ‐heterocycle products in good to excellent yields at room temperature in DMF. In addition, the supported Cu(I) catalyst could be recovered at least 10 times without significant loss of its catalytic activity . Copyright © 2012 John Wiley & Sons, Ltd.