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Synthesis, structural characterization and antimicrobial activity of mixed aryl–alkyl diorganotin(IV) compounds with quinoline‐2‐carboxylate (L − ): {RR′SnLCl} n and RR′SnL 2
Author(s) -
Vafaee Marzieh,
Amini Mostafa M.,
Khavasi Hamid Reza,
Ng Seik Weng,
Tiekink Edward R. T.
Publication year - 2012
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.2890
Subject(s) - chemistry , carboxylate , stereochemistry , octahedral molecular geometry , chelation , alkyl , supramolecular chemistry , aryl , ligand (biochemistry) , antimicrobial , crystallography , medicinal chemistry , crystal structure , organic chemistry , biochemistry , receptor
A series of unsymmetrical diorganotin derivatives of quinoline‐2‐carboxylic acid (LH), namely polymeric {MePhSnClL} n (1) and {EtPhSnClL} n (2), and mononuclear MePhSnL 2 (3) and EtPhSnL 2 (4), was synthesized by the reaction of LH with the MePhSnCl 2 , EtPhSnCl 2 , MePhSnO, and EtPhSnO precursors, respectively. The compounds were characterized by elemental analysis and infrared spectroscopy, as well as by 1 H, 13 C and 119 Sn NMR. The molecular structures of representative compounds 2 and 4 were determined by single‐crystal X‐ray crystallography. This study showed that polymeric 2 adopts a distorted octahedral geometry as the carboxylate ligand N,O chelates an Sn atom and at the same time bridges a neighbouring Sn atom via the second O atom, with the remaining sites being occupied by the Cl and two C atoms; the O atoms are trans to each other. The result of the μ 2 ‐bridging mode of L − is the formation of a supramolecular helical chain. Compound 4 adopts a skew‐trapezoidal bipyramidal geometry with the organo groups lying over the plane of the two N,O‐chelating carboxylate ligands and being directed over the weaker Sn―N bonds. The in vitro antimicrobial activities of 1–4 against a Gram‐positive bacteria strain ( Bacillus subtilis ), a Gram‐negative bacteria strain ( Escherichia coli ) and against Candida albicans were studied and compared with the antimicrobial activities of Ph 2 SnL 2 and Me 2 SnL 2 , and with the antimicrobial standards gentamicin, tetracycline, ampicillin and penicillin. All organotin compounds displayed remarkable antibacterial activities that were comparable to those of the standard drugs, in particular against B. subtilis , where the activity was correlated with the number of Cl substituents. Copyright © 2012 John Wiley & Sons, Ltd.