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Efficient salicylaldimine ligands for a palladium‐catalyzed Suzuki–Miyaura cross‐coupling reaction
Author(s) -
Liu FengShou,
Huang YingTang,
Lu Chao,
Shen DongSheng,
Cheng Tao
Publication year - 2012
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.2875
Subject(s) - chemistry , moiety , aryl , palladium , coupling reaction , catalysis , substituent , combinatorial chemistry , cyclohexylamine , ligand (biochemistry) , organic chemistry , medicinal chemistry , alkyl , biochemistry , receptor
A series of salicylaldimine ligands were designed to promote palladium‐catalyzed Suzuki–Miyaura cross‐coupling reaction. After a screening process, a ligand with a bulky 2,4‐di‐ tert ‐butyl substituent on the salicyaldehyde backbone and cyclohexylamine moiety was found to serve as a good combination for this reaction in aqueous solutions of DMF. The protocol demonstrated a significant advance in the efficiency of the cross‐coupling of aryl bromides and aryl chlorides with arylboronic acids to produce the desired biaryl products. Copyright © 2012 John Wiley & Sons, Ltd.