Efficient salicylaldimine ligands for a palladium‐catalyzed Suzuki–Miyaura cross‐coupling reaction | Zendy

Liu FengShou | Zendy; Huang YingTang | Zendy; Lu Chao | Zendy; Shen DongSheng | Zendy; Cheng Tao | Zendy

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Efficient salicylaldimine ligands for a palladium‐catalyzed Suzuki–Miyaura cross‐coupling reaction

Author(s) -

Liu FengShou,

Huang YingTang,

Lu Chao,

Shen DongSheng,

Cheng Tao

Publication year - 2012

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.2875

Subject(s) - chemistry , moiety , aryl , palladium , coupling reaction , catalysis , substituent , combinatorial chemistry , cyclohexylamine , ligand (biochemistry) , organic chemistry , medicinal chemistry , alkyl , biochemistry , receptor

A series of salicylaldimine ligands were designed to promote palladium‐catalyzed Suzuki–Miyaura cross‐coupling reaction. After a screening process, a ligand with a bulky 2,4‐di‐ tert ‐butyl substituent on the salicyaldehyde backbone and cyclohexylamine moiety was found to serve as a good combination for this reaction in aqueous solutions of DMF. The protocol demonstrated a significant advance in the efficiency of the cross‐coupling of aryl bromides and aryl chlorides with arylboronic acids to produce the desired biaryl products. Copyright © 2012 John Wiley & Sons, Ltd.

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