Synthesis, characterization and bioactivity determination of ferrocenyl urea derivatives | Zendy

Liu Wei | Zendy; Tang Yanting | Zendy; Guo Yu | Zendy; Sun Bo | Zendy; Zhu Hemin | Zendy; Xiao Yanyan | Zendy; Dong Dandan | Zendy; Yang Cheng | Zendy

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Synthesis, characterization and bioactivity determination of ferrocenyl urea derivatives

Author(s) -

Liu Wei,

Tang Yanting,

Guo Yu,

Sun Bo,

Zhu Hemin,

Xiao Yanyan,

Dong Dandan,

Yang Cheng

Publication year - 2012

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.2837

Subject(s) - chemistry , ferrocene , azide , protease , urea , linker , combinatorial chemistry , substrate (aquarium) , mass spectrometry , proton nmr , peptide , organic chemistry , chromatography , biochemistry , enzyme , oceanography , electrode , computer science , electrochemistry , geology , operating system

Fourteen new ferrocene derivatives containing urea linker were synthesized from the reaction of ferrocenecarbonyl azide with aromatic amines. The structures of the synthetic compounds were confirmed by 1 H NMR, 13 C NMR, IR, mass spectrometry and elemental analysis. These organometallic compounds were evaluated by in vitro protease assay using fluorogenic substrate peptide, and several showed potent inhibition against HIV‐1 protease. Copyright © 2012 John Wiley & Sons, Ltd.

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