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Synthesis, characterization and bioactivity determination of ferrocenyl urea derivatives
Author(s) -
Liu Wei,
Tang Yanting,
Guo Yu,
Sun Bo,
Zhu Hemin,
Xiao Yanyan,
Dong Dandan,
Yang Cheng
Publication year - 2012
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.2837
Subject(s) - chemistry , ferrocene , azide , protease , urea , linker , combinatorial chemistry , substrate (aquarium) , mass spectrometry , proton nmr , peptide , organic chemistry , chromatography , biochemistry , enzyme , oceanography , electrode , computer science , electrochemistry , geology , operating system
Fourteen new ferrocene derivatives containing urea linker were synthesized from the reaction of ferrocenecarbonyl azide with aromatic amines. The structures of the synthetic compounds were confirmed by 1 H NMR, 13 C NMR, IR, mass spectrometry and elemental analysis. These organometallic compounds were evaluated by in vitro protease assay using fluorogenic substrate peptide, and several showed potent inhibition against HIV‐1 protease. Copyright © 2012 John Wiley & Sons, Ltd.