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Synthesis, characterization of diorganotin(IV) complexes of N ‐(2‐hydroxyarylidene)amino‐acetic acid and antitumour screening in vivo in Ehrlich ascites carcinoma cells
Author(s) -
Basu Baul Tushar S.,
Dutta Sushmita,
Rivarola Eleonora,
Scopelliti Michelangelo,
Choudhuri Soumitra
Publication year - 2001
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.245
Subject(s) - chemistry , ehrlich ascites carcinoma , in vivo , tin , nuclear magnetic resonance spectroscopy , stereochemistry , mössbauer spectroscopy , hexa , proton nmr , medicinal chemistry , nuclear chemistry , in vitro , crystallography , organic chemistry , biochemistry , microbiology and biotechnology , biology
Some new diorganotin(IV) complexes havebeen prepared by reacting potassium N ‐(2‐hydroxyarylidene)aminoacetate with R 2 SnCl 2 (R =Me, n Bu,Ph). The complexes have been characterized by 1 H, 13 C, 119 Sn NMR, IR and 119m Sn Mössbauer spectroscopic techniques in combination with elemental analysis. In the solid state, the complexes possess penta‐ and hexa‐coordinated tin centres. The hexa‐coordinated tin complexes were found to dissociate in solution, giving rise to penta‐coordinated speciesas revealed by 119 Sn NMR spectroscopy. Antitumour screening in vivo of the complexes L 4 SnPh 2 ,L 4 SnPh 2 ·Ph 3 SnCl and L 4 Sn t Bu 2 · t Bu 2 SnCl 2 (L 4 = N ‐(2‐hydroxyacetophenone)aminoacetate) is also reported. Copyright © 2001 John Wiley & Sons, Ltd.