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DNA damage induced by organotins on trout‐nucleated erythrocytes
Author(s) -
Tiano Luca,
Fedeli Donatella,
Moretti Massimo,
Falcioni Giancarlo
Publication year - 2001
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.207
Subject(s) - chemistry , tributyltin , chloride , rainbow trout , dna damage , trout , gel electrophoresis , biofouling , biocide , genotoxicity , dna , environmental chemistry , biochemistry , toxicity , fishery , organic chemistry , membrane , fish <actinopterygii> , biology
The effect of tributyltin‐chloride (TBTC), dibutyltin‐chloride (DBTC) and monobutyltin‐chloride (MBTC) on rainbow trout ( Salmo irideus ) nuclear DNA, was investigated by means of single cell gel electrophoresis (‘comet’ assay). Our data show that TBTC presents a marked genotoxic effect, whereas the genotoxic effect is less pronounced for DBTC and it is completely absent for MBTC. These results could be important in evaluating the environmental risks deriving from the use of these molecules as a antifouling agents in marine paints and as agricultural biocides. Copyright © 2001 John Wiley & Sons, Ltd. Abbreviations: TBTC, tributyltin‐chloride;DBTC, dibutyltin‐chloride;MBTC, monobutyltin‐chloride;Hb, hemoglobin.