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Di‐ n ‐butyltin(IV) derivatives of bis(carboxymethyl)benzylamines: synthesis, NMR and X‐ray structure characterization and in vitro antitumour properties
Author(s) -
Mancilla Teresa,
Carrillo Lourdes,
Zamudio Rivera Luis S.,
Camacho Camacho Carlos,
Vos Dick de,
Kiss Robert,
Darro Francis,
Mahieu Bernard,
Tiekink Edward R. T.,
Rahier Hubert,
Gielen Marcel,
Kemmer Martine,
Biesemans Monique,
Willem Rudolph
Publication year - 2001
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.205
Subject(s) - chemistry , trigonal bipyramidal molecular geometry , nuclear magnetic resonance spectroscopy , tin , mössbauer spectroscopy , stereochemistry , derivative (finance) , mass spectrometry , solid state , crystallography , crystal structure , organic chemistry , chromatography , financial economics , economics
Four di‐ n ‐butyltin(IV) derivatives of bis(carboxymethyl)benzylamines were synthesized and their structure characterized by 1 H, 13 C and 117/119 Sn NMR, Mössbauer spectroscopy and mass spectrometry. The derivative substituted in the meta position by a methyl group has been further characterized by X‐ray crystallography. This compound exhibits a distorted trigonal bipyramidal geometry at tin. The NMR data in solution, as well as other spectroscopic results in the solid state, confirm this structure for all the compounds. Evidence is provided to show that the compounds are more highly associated in concentrated solution than in the solid state. Their in vitro antitumour activity is reported. Copyright © 2001 John Wiley & Sons, Ltd.