Synthesis and  in vitro  antitumor activity of some tetraphenylantimony derivatives of  exo ‐7‐oxa‐bicyclo[2,2,1] heptane (ene)‐3‐arylamide‐2‐acid | Zendy

Li JinShan | Zendy; Ma YongQiang | Zendy; Cui JingRong | Zendy; Wang RuiQing | Zendy

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Synthesis and in vitro antitumor activity of some tetraphenylantimony derivatives of exo ‐7‐oxa‐bicyclo[2,2,1] heptane (ene)‐3‐arylamide‐2‐acid

Author(s) -

Li JinShan,

Ma YongQiang,

Cui JingRong,

Wang RuiQing

Publication year - 2001

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.200

Subject(s) - chemistry , bicyclic molecule , heptane , stereochemistry , ene reaction , crystal structure , in vitro , crystallography , organic chemistry , biochemistry

A series of novel tetraphenylantimony derivatives of exo ‐7‐oxa‐bicyclo[2,2,1] heptane (ene)‐3‐arylamide‐2‐acid of the general formula Ph 4 SbO 2 CCHCHCH 2 CH 2 CH(O)HCONHAr (Ar = Ph,4‐ClC 6 H 4 , 4‐BrC 6 H 4 , 3‐BrC 6 H 4 , 4‐F‐3‐ClC 6 H 3 and 4‐ MeC 6 H 4 ) have been synthesized and characterized by elemental analysis, IR, 1 H NMR and mass spectra. The crystal structure of Ph 4 SbO 2 CCHCHCH 2 CH 2 CH(O)HCONHC 6 H 4 CH 3 ·CHCl 3 was determined by X‐ray diffraction. Five human neoplastic cell lines (HL‐60, KB, Bel‐7402, BGC‐823 and HCT‐8) were used to screen these compounds. The results indicate that these compounds at 10 µ M show certain in vitro antitumor activities. Copyright © 2001 John Wiley & Sons, Ltd.

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