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Transition metal complexes of 1,2‐dihydroquinazolinone derivative, an emerging class of analgesic and anti‐inflammatory agents
Author(s) -
Badiger Dayananda S.,
Nidavani Ramesh B.,
Hunoor Rekha S.,
Patil Basavaraj R.,
Vadavi Ramesh S.,
Chandrashekhar V. M.,
Muchchandi Iranna S.,
Gudasi Kalagouda B.
Publication year - 2011
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1855
Subject(s) - chemistry , heteronuclear molecule , ligand (biochemistry) , metal , trigonal bipyramidal molecular geometry , magnetic susceptibility , stereochemistry , transition metal , metal ions in aqueous solution , derivative (finance) , analgesic , crystallography , medicinal chemistry , nuclear magnetic resonance spectroscopy , crystal structure , organic chemistry , medicine , biochemistry , receptor , financial economics , economics , pharmacology , catalysis
A new 1,2‐dihydroquinazolinone, 2‐(2‐hydroxy‐phenyl)‐3‐[1‐(2‐oxo‐2 H ‐chromen‐3‐yl)‐ethylideneamino]‐2,3‐dihydro‐1 H ‐quinazolin‐4‐one (L) and its Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes have been prepared. These were characterized by elemental, spectral [UV–visible, IR, NMR ( 1 H, 13 C and 2D heteronuclear correlation) and mass], conductance, magnetic susceptibility and thermal studies. The physicochemical data indicate that the ligand behaves as tridentate with ONO donor sequence towards the metal ions, and trigonal bipyramidal geometry was assigned for complexes. The ligand and its metal complexes were evaluated for their in vivo anti‐inflammatory and analgesic activity. The tested compounds have shown excellent activity, which are almost equipotent to the standard used in the study. Copyright © 2011 John Wiley & Sons, Ltd.