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Synthesis, structure and cytotoxic activity of binuclear phenyltin(IV) complexes with N , N ′‐ bis (2‐hydroxybenzyl)‐1,2‐ethane bis (dithiocarbamate) ligand
Author(s) -
Tian Laijin,
Zheng Xiaofeng,
Zheng Xiaoliang,
Sun Yuxi,
Yan Dongmei,
Tu Linglan
Publication year - 2011
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1834
Subject(s) - dithiocarbamate , chemistry , ligand (biochemistry) , crystal structure , crystallography , tin , stereochemistry , molecule , trigonal bipyramidal molecular geometry , square pyramidal molecular geometry , hydrogen bond , bipyramid , supramolecular chemistry , organic chemistry , biochemistry , receptor
Two new dinuclear phenyltin(IV) complexes derived from N , N ′‐ bis (2‐hydroxybenzyl)‐1,2‐ethane bis (dithiocarbamate) ligand, [2‐HOC 6 H 4 CH 2 N(CS 2 SnPh 3 )CH 2 ] 2 ( 1 ) and [2‐HOC 6 H 4 CH 2 N(CS 2 SnClPh 2 )CH 2 ] 2 ( 2 ) have been synthesized and characterized by elemental analysis, IR and NMR ( 1 H, 13 C and 119 Sn) spectra. The crystal structures of complexes 1 and 2 were determined by X‐ray single crystal diffraction and show that the dithiocarbamate ligand is coordinated to the tin atom in the anisobidentate manner and the tin atom is five‐coordinated. The coordination geometry of tin atom is best described as an intermediate between trigonal bipyramidal and square pyramidal with τ‐values of 0.63 and 0.53, respectively. Intermolecular hydrogen bonds (OH···S and OH···Cl) in 1 and 2 connect neighboring molecules into a one‐dimensional supramolecular chain with the centrosymmetric cyclic motifs. Complex 1 has potent in vitro cytotoxic activity against two human tumor cell lines, CoLo205 and Bcap37, while complex 2 displays weak cytotoxic activity. Copyright © 2011 John Wiley & Sons, Ltd.