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S , N ‐Chelated organotin(IV) compounds containing 6‐phenylpyridazine‐3‐thiolate ligand—structural, antibacterial and antifungal study
Author(s) -
Ozerianskyi Andrii,
Švec Petr,
Vaňkátová Hana,
Vejsová Marcela,
Česlová Lenka,
Padělková Zdeňka,
Růžička Aleš,
Holeček Jaroslav
Publication year - 2011
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1823
Subject(s) - chemistry , chelation , ligand (biochemistry) , tin , antifungal , stereochemistry , medicinal chemistry , nuclear magnetic resonance spectroscopy , organic chemistry , medicine , biochemistry , receptor , dermatology
A series of tri‐ and diorganotin(IV) compounds containing potentially chelating S , N ‐ligand(s) (L SN , where L SN is 6‐phenylpyridazine‐3‐thiolate) were prepared and structurally characterized by multinuclear NMR spectroscopy. X‐ray diffraction techniques were used for determination of the structure of compounds containing one [(L SN )Ph 2 SnCl], two [( n ‐Bu) 2 Sn(L SN ) 2 ] and the combination of two L SN and one L CN [(L CN )( n ‐Bu)Sn(L SN ) 2 ] (where L CN is {2‐[(CH 3 ) 2 NCH 2 ]C 6 H 4 }‐) ligands. The coordination number of the tin atom varies from five to seven and is dependent on the number of chelating ligands present. The formation of the five‐membered azastanna heterocycle is favored over the formation of four‐membered azastannathia heterocycle in compounds containing both types of ligands. The di‐ n ‐butyl‐substituted compounds are the most efficient ones in inhibition of growth of yeasts, molds and G + bacteria strains. Copyright © 2011 John Wiley & Sons, Ltd.