Regioselective synthesis of 1,4‐disubstituted triazoles using  bis [(L)prolinato‐N,O]Zn complex as an efficient catalyst in water as a sole solvent | Zendy

Kidwai Mazaahir | Zendy; Jain Arti | Zendy

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Regioselective synthesis of 1,4‐disubstituted triazoles using bis [(L)prolinato‐N,O]Zn complex as an efficient catalyst in water as a sole solvent

Author(s) -

Kidwai Mazaahir,

Jain Arti

Publication year - 2011

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.1816

Subject(s) - chemistry , regioselectivity , sodium azide , aryl , catalysis , alkyne , alkyl , zinc , solvent , azide , halide , organic chemistry , combinatorial chemistry , medicinal chemistry

A concise, convenient and mild route for one‐pot regioselective synthesis of N ‐aryl‐ and N ‐alkyltriazoles in water as a sole solvent is reported. The methodology involves a three‐component reaction comprising aryl/alkyl‐alkyne, sodium azide and aryl/alkyl/allyl halide catalyzed by zinc(II) L ‐prolinate. Prominent features of our protocol are incorporation of transition metal catalyst other than copper, water as the reaction medium, recyclability of catalyst and avoidance of hazardous aryl azide as a reactant. Copyright © 2011 John Wiley & Sons, Ltd.

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