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Synthesis and antimicrobial studies of bis ( O , O ′‐dialkyl and alkylene dithiophosphoric acid) adducts of diphenyl diselenide
Author(s) -
Khaldy A. A. S. El,
Abushanab A. M.,
Alkhair Emad Abu
Publication year - 2011
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1791
Subject(s) - chemistry , adduct , diselenide , benzene , monomer , medicinal chemistry , yield (engineering) , proton nmr , molar ratio , carbon 13 nmr , polymer chemistry , nuclear chemistry , stereochemistry , organic chemistry , catalysis , selenium , materials science , metallurgy , polymer
Dialkyl and alkylene dithiophoshoric acids react with diphenyl diselenide in a 1:2 molar ratio in refluxing benzene to yield Ph 2 Se 2 ·2HS 2 P(OR) 2 (R = Et, Pr‐n, Pr‐i, Bu‐i and Ph) and , where G = ‐CH 2 CMe 2 CH 2 ‐, ‐CH 2 CEt 2 CH 2 ‐ and ‐CMe 2 CMe 2 ‐. The complexes are yellow solids (in the cyclic chain) and yellow sticky solids (in the open chain), are soluble in common organic solvents and are monomeric in nature. They were characterized on the basis of elemental analyses, molecular weight determinations, IR and NMR ( 1 H, 13 C and 31 P). The spectral data revealed addition of dithiophosphate moieties to the diselenide. Studies were conducted to assess the growth‐inhibiting potential of some of the synthesized complexes against various bacterial strains. Copyright © 2011 John Wiley & Sons, Ltd.