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Synthesis, spectroscopic, thermal and biological aspects of drug‐based copper(II) complexes
Author(s) -
Patel Paresh N.,
Patel Darshana J.,
Patel Hasmukh S.
Publication year - 2011
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1786
Subject(s) - chemistry , copper , entropy of activation , octahedron , activation energy , enthalpy , serratia marcescens , phenol , proton nmr , stereochemistry , nuclear chemistry , crystallography , medicinal chemistry , escherichia coli , kinetics , reaction rate constant , organic chemistry , crystal structure , biochemistry , physics , quantum mechanics , gene
A series of novel complexes of the type Cu(II)(L n ) 2 (H 2 O) 2 ] • x H 2 O [where L n = L 1–4 , these ligands being described as: L 1 , 2‐({4‐[6,7‐dihydrothieno[3,2‐c]pyridin‐5(4H)‐ylsulfonyl]phenylimino}methyl)phenol, x = 1; L 2 , 2‐({4‐[6,7‐dihydrothieno[3,2‐c] pyridin‐5(4H)‐ylsulfonyl]phenylimino}methyl)‐5‐(methoxy)phenol, x = 2; L 3 , 5‐chloro‐2‐({4‐[6,7‐dihydrothieno[3,2‐c]pyridin‐5(4H)‐ylsulfonyl]phenylimino}methyl)phenol, x = 2; and L 4 , 5‐bromo‐4‐chloro‐2‐({4‐[6,7‐dihydrothieno[3,2‐c]pyridin‐5(4H)‐ylsulfonyl]phenylimino} methyl)phenol, x = 1] was investigated. They were characterized by elemental analysis, IR, 1 H‐NMR, 13 C‐NMR and electronic spectra, magnetic measurements and thermal studies. The FAB‐mass spectrum of [Cu(II)( L 1 ) 2 (H 2 O) 2 ] • H 2 O was determined. A magnetic moment and reflectance spectral study revealed that an octahedral geometry could be assigned to all the prepared complexes. Ligands (L n ) and their metal complexes were screened for their in vitro antibacterial activity against Bacillus subtillis, Pseudomonas aeruginosa, Escherichia coli and Serratia marcescens bacterial strains. Kinetic parameters such as order of reaction ( n ), the energy of activation ( E a ), the pre‐exponential factor ( A ), the activation entropy (Δ S ≠ ), the activation enthalpy (Δ H ≠ ) and the free energy of activation (Δ G ≠ ) are reported. Copyright © 2011 John Wiley & Sons, Ltd.