Premium
Structural studies of diethyltin(IV) derivatives and their biological aspects as potential antitumor agents against Agrobacterium tumefacien cells
Author(s) -
Hussain Mukhtiar,
Hanif Muhammad,
Altaf Muhammad,
Ali Saqib,
Cavell Kingsley J.
Publication year - 2011
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1777
Subject(s) - chemistry , stereochemistry , intermolecular force , crystal structure , single crystal , crystallography , dna , x ray crystallography , molecule , diffraction , organic chemistry , biochemistry , physics , optics
A series of new diethyltin(IV) derivatives of substituted phenyl acrylates have been synthesized and characterized by elemental analysis, IR, multinuclear NMR ( 1 H, 13 C, 19 F and 119 Sn) and X‐ray single crystal analysis. X‐ray single crystal diffraction study of complex 8 has shown the formation of secondary O···Sn, F···H and H···O intermolecular interactions. These complexes proved to be good antitumor agents. The antitumor properties are presumably due to the intercalative mode of interaction of these complexes with the tumor cells' DNA. Copyright © 2011 John Wiley & Sons, Ltd.