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Synthesis, microwave‐promoted catalytic activity in Suzuki–Miyaura cross‐coupling reactions and antimicrobial properties of novel benzimidazole salts bearing trimethylsilyl group
Author(s) -
Yılmaz Ülkü,
Küçükbay Hasan,
Şireci Nihat,
Akkurt Mehmet,
Günal Selami,
Durmaz Rıza,
Nawaz Tahir M.
Publication year - 2011
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1772
Subject(s) - benzimidazole , chemistry , yield (engineering) , trimethylsilyl , aryl , catalysis , coupling reaction , combinatorial chemistry , microanalysis , organic chemistry , antifungal , medicinal chemistry , alkyl , materials science , metallurgy , medicine , dermatology
A mixture of benzimidazole salts (2–7), Pd(OAc) 2 and K 2 CO 3 in DMF–H 2 O catalyzes the Suzuki–Miyaura cross‐coupling reactions promoted by microwave irradiation resulting in high yield within a short time. In particular, the yield of the Suzuki–Miyaura reactions with aryl bromides was found to be nearly quantitative. The synthesized benzimidazole salts (2–7) were identified by 1 H‐ 13 C, NMR, IR spectroscopic methods and microanalysis. The molecular structure of 1 was determined by X‐ray crystallography. The antibacterial and antifungal activities of the novel benzimidazole derivatives (1–7) were also tested against standard strains. Copyright © 2011 John Wiley & Sons, Ltd.
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