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Synthesis, characterization, antimicrobial, SOD mimic and DNA interaction behavior of copper(II) complexes with pefloxacin and phenanthroline derivatives
Author(s) -
Patel Mohan,
Gandhi Deepen,
Parmar Pradhuman
Publication year - 2011
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1766
Subject(s) - chemistry , pefloxacin , puc19 , phenanthroline , copper , square pyramidal molecular geometry , dna , stereochemistry , in vitro , antibacterial activity , gel electrophoresis , staphylococcus aureus , antioxidant , combinatorial chemistry , biochemistry , organic chemistry , bacteria , antibiotics , ofloxacin , ciprofloxacin , biology , plasmid , genetics
Square pyramidal copper(II) complexes with second‐generation fluoroquinolone, pefloxacin and phenanthroline derivatives were prepared and characterized. They were also screened for in–vitro activity against two Gram (+ve) and three Gram (−ve) microorganisms. SOD mimic behavior was actively sought for clinical and mechanistic purposes under a nonenzymatic system (NBT–NADH–PMS), and was found to have good antioxidant activity. The complexes are avid DNA binders having binding constant ( K b ) in the power of 4. Viscosity measurement data confirmed that complexes bind through classical intercalative mode of binding. The cleavage ability on pUC19 DNA was determined using gel electrophoresis technique. Copyright © 2011 John Wiley & Sons, Ltd.