Synthesis, characterization, antimicrobial, SOD mimic and DNA interaction behavior of copper(II) complexes with pefloxacin and phenanthroline derivatives | Zendy

Patel Mohan | Zendy; Gandhi Deepen | Zendy; Parmar Pradhuman | Zendy

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Synthesis, characterization, antimicrobial, SOD mimic and DNA interaction behavior of copper(II) complexes with pefloxacin and phenanthroline derivatives

Author(s) -

Patel Mohan,

Gandhi Deepen,

Parmar Pradhuman

Publication year - 2011

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.1766

Subject(s) - chemistry , pefloxacin , puc19 , phenanthroline , copper , square pyramidal molecular geometry , dna , stereochemistry , in vitro , antibacterial activity , gel electrophoresis , staphylococcus aureus , antioxidant , combinatorial chemistry , biochemistry , organic chemistry , bacteria , antibiotics , ofloxacin , ciprofloxacin , biology , plasmid , genetics

Square pyramidal copper(II) complexes with second‐generation fluoroquinolone, pefloxacin and phenanthroline derivatives were prepared and characterized. They were also screened for in–vitro activity against two Gram (+ve) and three Gram (−ve) microorganisms. SOD mimic behavior was actively sought for clinical and mechanistic purposes under a nonenzymatic system (NBT–NADH–PMS), and was found to have good antioxidant activity. The complexes are avid DNA binders having binding constant ( K b ) in the power of 4. Viscosity measurement data confirmed that complexes bind through classical intercalative mode of binding. The cleavage ability on pUC19 DNA was determined using gel electrophoresis technique. Copyright © 2011 John Wiley & Sons, Ltd.

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