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Synthesis, characterization and cytotoxic activity of new diorganotin(IV) complexes of N ‐(3,5‐dibromosalicylidene)tryptophane
Author(s) -
Tian Laijin,
Liu Xicheng,
Zheng Xiaoliang,
Sun Yuxi,
Yan Dongmei,
Tu Linglan
Publication year - 2011
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1758
Subject(s) - chemistry , trigonal bipyramidal molecular geometry , stereochemistry , crystallography , crystal structure , molecule , intermolecular force , square pyramidal molecular geometry , tin , bipyramid , atom (system on chip) , x ray crystallography , diffraction , organic chemistry , physics , computer science , optics , embedded system
Four new diorganotin(IV) complexes of N ‐(3,5‐dibromosalicylidene)tryptophane, R 2 Sn[3,5‐Br 2 ‐2‐OC 6 H 2 CHNCH(CH 2 Ind)COO] [Ind = 3‐indolyl; R = Et (1); n ‐Bu (2); Cy (3); Ph (4)], were synthesized and characterized by elemental analysis and IR, NMR ( 1 H, 13 C and 119 Sn) spectra. The crystal structures of complexes 1–3 were determined by X‐ray single crystal diffraction. The tin atom is five‐coordinated and its coordination geometry is best described as an intermediate between trigonal bipyramidal and square pyramidal. Intermolecular weak interactions in the complexes 1–3 connect molecules into a one‐dimensional helical chain and a two‐dimensional array. The dibutyltin complex 2 has potent in vitro cytotoxic activity against two human tumor cell lines, CoLo205 and Bcap37, while the diethyltin complex 1 displays weak cytotoxic activity. Copyright © 2011 John Wiley & Sons, Ltd.