Synthesis, structure and cytotoxic activity of new 1‐[5‐organylsilyl(germyl)‐2‐furyl (thienyl)]nitroethenes | Zendy

Ignatovich Luba | Zendy; Muravenko Velta | Zendy; Romanovs Vitalijs | Zendy; Sleiksha Ilze | Zendy; Shestakova Irina | Zendy; Domrachova Ilona | Zendy; Belyakov Sergey | Zendy; Popelis Jury | Zendy; Lukevics Edmunds | Zendy

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Synthesis, structure and cytotoxic activity of new 1‐[5‐organylsilyl(germyl)‐2‐furyl (thienyl)]nitroethenes

Author(s) -

Ignatovich Luba,

Muravenko Velta,

Romanovs Vitalijs,

Sleiksha Ilze,

Shestakova Irina,

Domrachova Ilona,

Belyakov Sergey,

Popelis Jury,

Lukevics Edmunds

Publication year - 2010

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.1712

Subject(s) - chemistry , nitromethane , ammonium acetate , substituent , catalysis , condensation reaction , stereochemistry , cytotoxicity , medicinal chemistry , organic chemistry , high performance liquid chromatography , in vitro , biochemistry

New highly cytotoxic 1‐[5‐organylsilyl(germyl)‐2‐furyl(thienyl)]nitroethenes (IC 50 0.3–3 µg ml −1 ) have been prepared by condensation reaction of corresponding silicon‐ and germanium‐containing heterocyclic aldehydes with nitromethane using ammonium acetate as the catalyst. The desired nitroethenes were identified by NMR ( 1 H, 13 C and 29 Si), IR, HRMS and GC‐MS spectra. The structure of 1‐(5‐triphenylsilyl‐2‐thienyl)nitroethene was studied by X‐ray. The influence of the substituent structure on the cytotoxicity was investigated. Copyright © 2010 John Wiley & Sons, Ltd.

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