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Heck coupling reaction using monomeric ortho ‐palladated complex of 4‐methoxy‐ benzoylmethylenetriphenylphosphorane under microwave irradiation
Author(s) -
Hajipour Abdol R.,
Karami Kazem,
Tavakoli Ghazal
Publication year - 2010
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1705
Subject(s) - chemistry , microwave irradiation , catalysis , heck reaction , microwave heating , halide , monomer , aryl , microwave , irradiation , coupling reaction , medicinal chemistry , palladium , reaction conditions , polymer chemistry , photochemistry , organic chemistry , polymer , alkyl , nuclear physics , physics , quantum mechanics
The activity of [Pd(C 6 H 4 CH 2 NH 2 ‐κ 2 ‐C‐N)PPh 3 MOBPPY]OTf complex, A (MOBPPY = 4‐methoxybenzoylmethylenetriphenyl‐ phosphoraneylide), was investigated in the Heck–Mizoroki CC cross‐coupling reaction under conventional heating and microwave irradiation conditions. The complex is an active and efficient catalyst for the Heck reaction of aryl halides. The yields were excellent using a catalytic amount of [Pd(C 6 H 4 CH 2 NH 2 ‐κ 2 ‐C‐N)PPh 3 MOBPPY]OTf complex in N ‐methyl‐2‐pyrrolidinone (NMP) at 130 °C and 600 W. In comparison to conventional heating conditions, the reactions under microwave irradiation gave higher yields in shorter reaction times. Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd.