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Synthesis, characterization, electrochemistry and evaluation of biological activities of some ferrocenyl Schiff bases
Author(s) -
Zaheer Muhammad,
Shah Afzal,
Akhter Zareen,
Qureshi Rumana,
Mirza Bushra,
Tauseef Misbah,
Bolte Michael
Publication year - 2011
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1690
Subject(s) - chemistry , aniline , condensation reaction , schiff base , electrochemistry , redox , single crystal , proton nmr , organic chemistry , polymer chemistry , crystallography , electrode , catalysis
Synthesis of ferrocenyl Schiff bases ( 1–6 ) was carried out by the condensation reaction of 4‐ferrocenyl aniline with different substituted aromatic aldehydes and acetyl acetone. Compounds were characterized by physical measurements, elemental analysis, FT‐IR, 1 H‐NMR and 13 C‐NMR spectroscopy. Single crystal X‐ray analysis of compound 2 showed the co‐planarity of both aromatic rings connected by a C–N double bond. Compounds demonstrated reversible one‐electron redox behavior and their peak currents were found to increase linearly with the square root of the sweep rate ν 1/2 . The overall electrode processes were found to be diffusion controlled. Compounds 1 and 4 showed low cytotoxicity and appreciable antifungal, antioxidant and DNA protection activities. Copyright © 2010 John Wiley & Sons, Ltd.