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Two novel diorganotin phosphonic diamides: syntheses, crystal structures, spectral properties and in vitro antibacterial studies
Author(s) -
Gholivand Khodayar,
Farshadian Sedigheh,
Hosseini Zahra,
Khajeh Khosro,
Akbari Neda
Publication year - 2010
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1669
Subject(s) - chemistry , trigonal bipyramidal molecular geometry , crystal structure , octahedron , single crystal , antibacterial activity , stereochemistry , crystallography , elemental analysis , proton nmr , nuclear magnetic resonance spectroscopy , chlorine atom , octahedral molecular geometry , medicinal chemistry , bacteria , organic chemistry , biology , genetics
Abstract Two diorganotin complexes with general formulae SnCl 2 (CH 3 ) 2 [C 6 H 5 P(O)(NHCH(CH 3 ) 2 ) 2 ] 2 ( 1 ) and SnCl 2 (CH 3 ) 2 [C 6 H 5 P(O) (NHC(CH 3 ) 3 ) 2 ] ( 2 ) were prepared by the addition of one equivalent SnCl 2 Me 2 to two equivalents of PhP(O)(NH i Pr) 2 and PhP(O)(NH t Bu) 2 , respectively. The compounds were characterized by elemental analysis, IR and multinuclear NMR ( 1 H, 13 C, 31 P and 119 Sn) spectroscopy. The crystal structures of the complexes were determined by X‐ray single crystal analysis, which revealed that complex 1 has a distorted octahedral geometry and complex 2 has a distorted trigonal bipyramidal structure with non‐equivalent chlorine atoms. Preliminary antibacterial tests of the compounds against Gram‐positive and ‐negative bacteria were carried out using the filter paper disk method and chloroamphenicol was used as standard for comparison. Copyright © 2010 John Wiley & Sons, Ltd.