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Palladium‐mediated synthesis of novel nimesulide derivatives
Author(s) -
Durgadas Shylaprasad,
Chatare Vijay kumar,
Mukkanti Khagga,
Pal Sarbani
Publication year - 2010
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1666
Subject(s) - chemistry , nimesulide , sonogashira coupling , palladium , aryl , combinatorial chemistry , heck reaction , stille reaction , in vivo , suzuki reaction , organic chemistry , medicinal chemistry , catalysis , biochemistry , alkyl , microbiology and biotechnology , biology
Synthesis of a series of compounds structurally related to the anti‐inflammatory agent nimesulide has been accomplished via Pd‐catalyzed CC bond forming reactions. Thus 4‐iodo derivative, prepared from nimesulide, participated in Sonogashira (copper‐free), Heck and Suzuki coupling reactions to afford the corresponding alkynyl, alkenyl and aryl substituted products. Some of the compounds synthesized were tested for anti‐inflammatory activities in vivo . Copyright © 2010 John Wiley & Sons, Ltd.