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Synthesis, structure and DNA cleavage of mononuclear Fe(III) complexes with 1,2,4‐triazole‐base ligand
Author(s) -
Liu Hui,
Kou Yingying,
Feng Li,
Li Dongdong,
Gao ChunYan,
Tian Jinlei,
Zhang Jingyan,
Yan Shiping
Publication year - 2010
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1659
Subject(s) - chemistry , cleavage (geology) , octahedron , crystal structure , crystallography , ligand (biochemistry) , dna , stereochemistry , octahedral molecular geometry , square pyramidal molecular geometry , single crystal , receptor , biochemistry , geotechnical engineering , fracture (geology) , engineering
Two new mononuclear iron(III) complexes, [Fe(HL) 2 ](ClO 4 ) · (H 2 O) 1.75 · CH 3 CN (1) and [Fe(HL)Cl 2 ] · DMF (2) [H 2 L = 3‐(2‐phenol)‐5‐(pyridin‐2‐yl)‐1,2,4‐triazole] have been synthesized and characterized by X‐ray single‐crystal structure analysis. The single crystal X‐ray crystallographic studies reveal that the central iron atom has a distorted octahedral environment for 1 and a distorted square pyramidal geometry for 2. The DNA cleavage activity of the iron(III) complexes was measured, indicating that the six‐coordinated iron(III) (complex 1) was cleavage inactive and only five‐coordinated complex 2 effectively promoted the cleavage of plasmid DNA in the presence and/or absence of activating agents (peroxide oxygen) at physiological pH and temperature. The mechanism of plasmid DNA cleavage was also studied by adding standard radical scavengers. Copyright © 2010 John Wiley & Sons, Ltd.
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