Premium
Synthesis and antimicrobial activities of sulfonohydrazide‐substituted 8‐hydroxyquinoline derivative and its oxinates
Author(s) -
Dixit Ritu B.,
Vanparia Satish F.,
Patel Tarosh S.,
Jagani Chandresh L.,
Doshi Hiren V.,
Dixit Bharat C.
Publication year - 2010
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1631
Subject(s) - chemistry , aspergillus niger , 8 hydroxyquinoline , antimicrobial , nuclear chemistry , escherichia coli , pseudomonas , hydrochloride , bacteria , organic chemistry , biochemistry , genetics , biology , gene
Looking at the pharmacological importance of 8‐hydroxyquinolines and sulfonamides, in the present study, a novel bi‐dentate ligand 4‐amino‐ N ′‐[(8‐hydroxyquinoline‐5‐yl)methyl] benzenesulfonohydrazide (AHQMBSH) having above both moieties within a single molecular framework was synthesized by the reaction of N ‐acetamidobenzene sulfonohydrazide with 5‐chloromethyl‐8‐hydroxyquinoline hydrochloride. Its metal(II) oxinates were also prepared with Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) salts. All the above compounds were investigated by physicochemical analyses, thermogravimetric analysis and spectroscopic techniques. Antimicrobial activities for the above prepared compounds were carried out using the agar‐plate method against various strains of bacteria ( Staphylococcus aureus, Bacillus subtillis, Pseudomonas aerugionsa, Escherichia coli ) and fungi ( Aspergillus niger and Aspergillus flavous ). The results show a significant increase in antimicrobial and antifungal activities of AHQMBSH compared with the parent 8‐hydroxyquinoline and sulfonamides. Copyright © 2010 John Wiley & Sons, Ltd.