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Synthesis and anticancer activity of chalcogenide derivatives and platinum(II) and palladium(II) complexes derived from a polar ferrocene phosphanyl–carboxamide
Author(s) -
Schulz Jiří,
Renfrew Anna K.,
Císařová Ivana,
Dyson Paul J.,
Štěpnička Petr
Publication year - 2010
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1626
Subject(s) - chemistry , platinum , palladium , ferrocene , carboxamide , medicinal chemistry , hydrogen peroxide , stereochemistry , sulfide , sulfur , catalysis , organic chemistry , electrochemistry , electrode
The polar phosphanyl‐carboxamide, 1′‐(diphenylphosphanyl)‐1‐[ N ‐(2‐hydroxyethyl)carbamoyl]ferrocene ( 1 ), reacts readily with hydrogen peroxide and elemental sulfur to give the corresponding phosphane‐oxide and phosphane‐sulfide, respectively, and with platinum(II) and palladium(II) precursors to afford various bis(phosphane) complexes [MCl 2 ( 1 ‐κ P ) 2 ] (M = trans ‐Pd, trans ‐Pt and cis ‐Pt). The anticancer activity of the compounds was evaluated in vitro with the complexes showing moderate cytotoxicities towards human ovarian cancer cells. Moreover, the biological activity was found to be strongly influenced by the stereochemistry, with trans ‐[PtCl 2 ( 1 ‐κ P ) 2 ] being an order of magnitude more active than the corresponding cis isomer. Copyright © 2010 John Wiley & Sons, Ltd.