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Iron oxide‐based magnetic nanostructures bearing cytotoxic organosilicon molecules for drug delivery and therapy
Author(s) -
Zablotskaya Alla,
Segal Izolda,
Lukevics Edmunds
Publication year - 2010
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1605
Subject(s) - chemistry , organosilicon , drug delivery , molecule , bilayer , nanoparticle , nanotechnology , iron oxide nanoparticles , magnetic nanoparticles , combinatorial chemistry , targeted drug delivery , iron oxide , organic chemistry , membrane , biochemistry , materials science
The results of our own investigation on synthesis, physico‐chemical and biological study of iron oxide based magnetic nanoparticles bearing cytotoxic organosilicon molecules of choline and colamine analogues, as potential agents for antitumor therapy, are summarized. These molecules contain hydrophilic head and long lipophilic tails, which are able to deepen inside the first surfactant shell (oleic acid), forming bilayer membrane like structures. Such compositions have a great privilege possessing magnetic properties, which in some cases could be essential moment in targeted drug delivery. The methodological approach has been developed and applied to the preparation of water soluble single or mixed coated biologically active nanoparticles of different types. Copyright © 2010 John Wiley & Sons, Ltd.