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Organocatalytic synthesis of cyanohydrin trimethylsilyl ethers by potassium 4‐benzylpiperidinedithiocarbamate under solvent‐free conditions
Author(s) -
Dekamin Mohammad G.,
Alizadeh Roghieh,
Reza NaimiJamal M.
Publication year - 2010
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1600
Subject(s) - cyanohydrin , chemistry , trimethylsilyl cyanide , trimethylsilyl , organic chemistry , potassium cyanide , potassium , solvent , cyanide , catalysis
Abstract Potassium 4‐benzylpiperidinedithiocarbamate was found to be an efficient organocatalyst for facile addition of trimethylsilyl cyanide to a wide variety of aldehydes and ketones to afford corresponding cyanohydrin trimethylsilyl ethers in high to quantitative yields. The reaction proceeded smoothly by employing 2.0 mol% PBPDC loading under mild conditions at room temperature within a very short reaction time. Copyright © 2009 John Wiley & Sons, Ltd.