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Reduction of nitroarenes followed by propanol group transfer from tris(3‐hydroxypropyl)‐ amine and cyclization leading to quinolines under heterogeneous PdC catalysis
Author(s) -
Cho Chan Sik,
Kim Tae Gyun,
Yoon Nam Sik
Publication year - 2010
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1596
Subject(s) - chemistry , amine gas treating , catalysis , tris , medicinal chemistry , tin , chloride , polymer chemistry , organic chemistry , biochemistry
Nitroarenes having electron‐donating or ‐withdrawing substituents are reduced to anilines and cyclized with tris(3‐hydroxypropyl)amine in the presence of a catalytic amount of PdC along with tin(II) chloride and isopropanol in dioxane‐H 2 O medium to give the corresponding quinolines in good to excellent yields. Copyright © 2009 John Wiley & Sons, Ltd.