Enantioselective addition of diethylzinc to aldehydes catalyzed by β‐amino alcohols derived from (1 R ,2 S )‐norephedrine | Zendy

Tasgin Dilek Isik | Zendy; Unaleroglu Canan | Zendy

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Enantioselective addition of diethylzinc to aldehydes catalyzed by β‐amino alcohols derived from (1 R ,2 S )‐norephedrine

Author(s) -

Tasgin Dilek Isik,

Unaleroglu Canan

Publication year - 2010

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.1583

Subject(s) - diethylzinc , chemistry , enantioselective synthesis , catalysis , alkylation , derivative (finance) , organic chemistry , financial economics , economics

β‐Amino alcohols derived from (1 R ,2 S )‐norephedrine were synthesized and used as ligands in the catalytic enantioselective diethylzinc addition to benzaldehydes. N ‐alkylated (1 R ,2 S )‐norephedrine‐based derivative 3a gave the highest enantioselectivity. The effects of different parameters on the enantioselectivity of the product were investigated. Copyright © 2009 John Wiley & Sons, Ltd.

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