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Enantioselective addition of diethylzinc to aldehydes catalyzed by β‐amino alcohols derived from (1 R ,2 S )‐norephedrine
Author(s) -
Tasgin Dilek Isik,
Unaleroglu Canan
Publication year - 2010
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1583
Subject(s) - diethylzinc , chemistry , enantioselective synthesis , catalysis , alkylation , derivative (finance) , organic chemistry , financial economics , economics
β‐Amino alcohols derived from (1 R ,2 S )‐norephedrine were synthesized and used as ligands in the catalytic enantioselective diethylzinc addition to benzaldehydes. N ‐alkylated (1 R ,2 S )‐norephedrine‐based derivative 3a gave the highest enantioselectivity. The effects of different parameters on the enantioselectivity of the product were investigated. Copyright © 2009 John Wiley & Sons, Ltd.