Premium
Preparation and cytotoxic properties of goethite‐based nanoparticles covered with decyldimethyl(dimethylaminoethoxy) silane methiodide
Author(s) -
Segal Izolda,
Zablotskaya Alla,
Lukevics Edmunds,
Maiorov Mikhail,
Zablotsky Dmitry,
Blums Elmars,
Mishnev Anatoly,
Georgieva Radostina,
Shestakova Irina,
Gulbe Anita
Publication year - 2010
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1573
Subject(s) - chemistry , nanoparticle , methiodide , goethite , dynamic light scattering , zeta potential , colloid , silane , chemical engineering , nuclear chemistry , nanotechnology , stereochemistry , organic chemistry , materials science , adsorption , engineering
Abstract The present work describes the synthesis, physico‐chemical and biological properties of the first water‐soluble goethite nanoparticles covered with biologically active components: oleic acid and cytotoxic decyldimethyl(dimethylaminoethoxy)silane methiodide. The structure of initial goethite nanoparticles synthesized was proved by XRD analysis and the rough estimation of nanoparticles core size gave the value of 8 nm. The size of colloidal water‐soluble nanoparticles, determined by dynamic light scattering, was within 19–35 nm. Magnetic properties and cytotoxicity (against HT‐1080 and MG‐22A tumor cell lines) of the nanoparticles obtained were investigated. Copyright © 2009 John Wiley & Sons, Ltd.