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Synthesis, characterization and DNA binding and photocleavage studies of [Ru(bpy) 2 BDPPZ] 2+ , [Ru(dmb) 2 BDPPZ] 2+ and [Ru(phen) 2 BDPPZ] 2+ complexes and their antimicrobial activity
Author(s) -
Ashwini Kumar K.,
Reddy Kotha Laxma,
Vidhisha S.,
Satyanarayana S.
Publication year - 2009
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1534
Subject(s) - chemistry , intercalation (chemistry) , bipyridine , ruthenium , ligand (biochemistry) , crystallography , triphenylene , stereochemistry , proton nmr , medicinal chemistry , inorganic chemistry , molecule , catalysis , crystal structure , organic chemistry , biochemistry , receptor
Polypyridyl ligand 9a,13a‐dihydro‐4,5,9,14‐tetraaza‐benzo[b]triphenylene‐11‐yl)‐phenyl‐methanone (BDPPZ) and its complexes [Ru(bpy) 2 BDPPZ] 2+ , [Ru(dmb) 2 BDPPZ] 2+ and [Ru(phen) 2 BDPPZ] 2+ (where bpy = 2,2′‐bipyridine, dmb = 4,4′‐dimethyl‐2,2′‐bipyridine, phen = 1,10‐phenanthroline) have been synthesized and characterized by elemental analysis, IR, UV–vis, 1 H‐NMR, 13 C‐NMR and mass spectra. The DNA‐binding properties of the complexes were investigated by absorption, emission, melting temperature and viscosity measurements. Experimental results indicate that the three complexes can intercalate into DNA base pairs. Photo activated cleavage of pBR‐322 DNA by the three complexes was also studied. Further, all three Ru(II) complexes synthesized were screened for their antimicrobial activity. Copyright © 2009 John Wiley & Sons, Ltd.