Synthesis of 2,4,6‐trisubstituted naphthalenes via novel copper‐promoted tandem coupling and intramolecular cyclization | Zendy

Wang Yuguang | Zendy; Zhu Bingchun | Zendy; Zhu Qin | Zendy

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Synthesis of 2,4,6‐trisubstituted naphthalenes via novel copper‐promoted tandem coupling and intramolecular cyclization

Author(s) -

Wang Yuguang,

Zhu Bingchun,

Zhu Qin

Publication year - 2009

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.1531

Subject(s) - chemistry , intramolecular force , tandem , combinatorial chemistry , copper , coupling (piping) , intramolecular reaction , coupling reaction , stereochemistry , cascade reaction , medicinal chemistry , organic chemistry , catalysis , mechanical engineering , materials science , engineering , composite material

An unprecedented copper‐promoted tandem coupling and intramolecular cyclization reaction is disclosed. This strategy offers a simple and promising method for accessing 2,4,6‐trisubstituted naphthalenes. A reaction mechanism involving initial formation of diynes followed by a 6‐ exo ‐dig cyclization and subsequent rearrangement is proposed. Copyright © 2009 John Wiley & Sons, Ltd.

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