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Synthesis of 2,4,6‐trisubstituted naphthalenes via novel copper‐promoted tandem coupling and intramolecular cyclization
Author(s) -
Wang Yuguang,
Zhu Bingchun,
Zhu Qin
Publication year - 2009
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1531
Subject(s) - chemistry , intramolecular force , tandem , combinatorial chemistry , copper , coupling (piping) , intramolecular reaction , coupling reaction , stereochemistry , cascade reaction , medicinal chemistry , organic chemistry , catalysis , mechanical engineering , materials science , engineering , composite material
Abstract An unprecedented copper‐promoted tandem coupling and intramolecular cyclization reaction is disclosed. This strategy offers a simple and promising method for accessing 2,4,6‐trisubstituted naphthalenes. A reaction mechanism involving initial formation of diynes followed by a 6‐ exo ‐dig cyclization and subsequent rearrangement is proposed. Copyright © 2009 John Wiley & Sons, Ltd.