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Antibacterial, spectral and thermal aspects of drug based‐Cu(II) mixed ligand complexes
Author(s) -
Kharadi G. J.,
Patel K. D.
Publication year - 2009
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1530
Subject(s) - chemistry , entropy of activation , activation energy , clioquinol , enthalpy , mass spectrum , antibacterial activity , ligand (biochemistry) , metal , denticity , copper , stereochemistry , kinetics , reaction rate constant , ion , organic chemistry , bacteria , thermodynamics , biochemistry , physics , genetics , receptor , pathology , quantum mechanics , biology , medicine
The antibiotic agent clioquinol is well known for its drug design and coordinating ability towards metal ions. Copper(II) mixed‐ligand complexes of clioquinol with various uninegative bidentate ligands were prepared. The structure of the synthesized complexes was characterized using elemental analyses, infrared spectra, 1 H‐NMR spectra, electronic spectra, magnetic measurements, FAB mass spectrum and thermo gravimetric analyses. The kinetic parameters such as order of reaction ( n ) and the energy of activation ( E a ) are reported using the Freeman–Carroll method. The pre‐exponential factor ( A ), the activation entropy (Δ S # ), the activation enthalpy (Δ H # ) and the free energy of activation (Δ G # ) were calculated. Complexes were also screened for their in vitro antibacterial activity against a range of Gram‐positive and Gram‐negative bacteria in order to set the precursors for anti‐tumourigenic agent. Copyright © 2009 John Wiley & Sons, Ltd.