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Synthesis, characterization and biological properties of sulfonamide‐derived compounds and their transition metal complexes
Author(s) -
Chohan Zahid H.,
Shad Hazoor A.,
Nasim FaizulHassan
Publication year - 2009
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1513
Subject(s) - chemistry , sulfonamide , transition metal , metal , zinc , chelation , nickel , octahedral molecular geometry , cobalt , antibacterial activity , ligand (biochemistry) , magnetic susceptibility , octahedron , stereochemistry , antifungal , mass spectrum , crystallography , medicinal chemistry , crystal structure , mass spectrometry , organic chemistry , bacteria , receptor , medicine , biochemistry , chromatography , dermatology , biology , genetics , catalysis
Sulfonamide‐derived compounds and their first row d‐transition metal chelates [cobalt(II), copper(II), nickel(II) and zinc(II)] have been synthesized and characterized. The nature of bonding and structure of all the synthesized compounds have been proposed from magnetic susceptibility and conductivity measurements, IR, 1 H and 13 C NMR, electron spectra, mass spectrometry and CHN analysis data. The structure of ligand, 4‐{[( E )‐(5‐chloro‐2‐hydroxyphenyl) methylidene] amino}‐ N ‐(4,6‐dimethyl pyrimidin‐2‐yl) benzene sulfonamide has also been determined by X‐ray diffraction method. An octahedral geometry has been suggested for all the complexes. The ligands and metal complexes have been screened for their in vitro antibacterial, antifungal and cytotoxic activity. The results of these studies revealed that all compounds showed moderate to significant antibacterial activity against one or more bacterial strains and good antifungal activity against various fungal strains. Copyright © 2009 John Wiley & Sons, Ltd.