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Reactivity of mixed organozinc and organocopper reagents. 3. Atom economic electrophilic amination of methyl arylzinc reagents
Author(s) -
Erdik Ender,
Ömür Pekel Özgen,
Kalkan Melike
Publication year - 2009
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1506
Subject(s) - chemistry , electrophilic amination , reagent , amination , electrophile , carbanion , reactivity (psychology) , aryl , atom economy , oxime , organic chemistry , acetone , combinatorial chemistry , medicinal chemistry , catalysis , alkyl , medicine , alternative medicine , pathology
Abstract Reaction of methyl arylzincs with acetone O ‐(mesitylenesulfonyl)oxime in THF in the presence of CuCN at room temperature is efficient in selective electrophilic amination of aryl carbanions. This procedure allows for the preparation of arylamines in moderate to good yields and provides an efficient and atom economic alternative to existing amination methods for diarylzincs. Copyright © 2009 John Wiley & Sons, Ltd.