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Simple route to ferrocenylalkyl nucleobases. Antitumor activity in vivo
Author(s) -
Simenel Alexander A.,
Morozova Elena A.,
Snegur Lubov' V.,
Zykova Svetlana I.,
Kachala Vadim V.,
Ostrovskaya Larissa A.,
Bluchterova Natalia V.,
Fomina Margarita M.
Publication year - 2009
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1500
Subject(s) - chemistry , lewis lung carcinoma , nucleobase , thymine , cytosine , in vivo , stereochemistry , uracil , combinatorial chemistry , dna , biochemistry , cancer , medicine , microbiology and biotechnology , biology , metastasis
Abstract Ferrocenylalkyl nucleobases ( 1 – 14 ) were prepared via the reaction of the α‐(hydroxy)alkyl ferrocenes FcCHR(OH) (Fc = ferrocenyl; R = H, Me, Et, Ph) with thymine, cytosine, iodo‐cytosine and adenine in DMSO at 100 °C, yields being 50–80%. The antitumor activities of ferrocenylmethyl thymine ( 1 ) against solid tumor models, carcinoma 755 (Ca755) and Lewis lung carcinoma (LLC) were studied in vivo . Therapeutic synergism of antitumor activity against LLC was demonstrated in the case of combined application of compound 1 with anticancer drug cyclophosphamide. Copyright © 2009 John Wiley & Sons, Ltd.