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Preparation of N ‐alkylpyridinium aryl ketone derivatives via the surfactant promoted cross‐coupling reaction of N ‐alkylpyridiniumboronic acids with carboxylic anhydride in water at room temperature
Author(s) -
Matondo H.,
Garrigues J. C.,
RicoLattes I.,
Lattes A.
Publication year - 2009
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1493
Subject(s) - chemistry , phosphine , aryl , ketone , coupling reaction , palladium , organic chemistry , ligand (biochemistry) , chloride , acyl chloride , suzuki reaction , benzoic acid , polymer chemistry , catalysis , medicinal chemistry , alkyl , biochemistry , receptor
The palladium (II) chloride catalyzed coupling reaction of N ‐alkylpyridiniumboronic acids with benzoic anhydride was carried out smoothly in water to give high yields of ketones without the use of a phosphine ligand. The reaction was conducted under mild conditions at room temperature. In this article, by focusing on the Suzuki reaction, it is shown how this method can impact modern synthetic chemistry, making reactions faster, easier and cleaner. Copyright © 2009 John Wiley & Sons, Ltd.