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Ecofriendly synthesis, antimicrobial and antispermatogenic activity of triorganotin(IV) complexes with 4′‐nitrobenzanilide semicarbazone and 4′‐nitrobezanilide thiosemicarbazone
Author(s) -
Chaudhary Pratibha,
Swami Monika,
Sharma D. K.,
Singh R. V.
Publication year - 2009
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1484
Subject(s) - semicarbazone , chemistry , trigonal bipyramidal molecular geometry , stereochemistry , antimicrobial , tin , medicinal chemistry , nuclear chemistry , molecule , organic chemistry
New series of triorganotin(IV) complexes with 4′‐nitrobenzanilide semicarbazone (L 1 H) and 4′‐nitrobenzanilide thiosemicarbazone (L 2 H) of the type [R 3 Sn(L)] (R = ‐CH 3 , ‐C 6 H 5 and n ‐C 4 H 9 ) were synthesized under microwave irradiation. All the complexes were characterized by elemental analysis, conductance measurements, molecular weight determinations and spectral data, viz., IR, UV–vis, 1 H, 13 C and 119 Sn NMR. The central tin atoms of these complexes are all five‐coordinated with trigonal bipyramidal geometry. In order to assess their growth inhibitory potency semicarbazone, thiosemicarbazone and their triorganotin(IV) complexes were tested in vitro against some pathogenic fungi and bacteria. Also the ligands and their organotin(IV) complexes were studied to assess the effects of long‐term ingestion of these compounds on fertility, body and reproductive organ weights. The biochemical analyses were also performed on blood samples and reproductive organs of male rats. The findings have been presented in this paper. Copyright © 2009 John Wiley & Sons, Ltd.