Premium
The effect of phenyltin chlorides on the phase polymorphism of dipalmitoylphosphatidylcholine
Author(s) -
RóżyckaRoszak Bożenna,
Pruchnik Hanna
Publication year - 2001
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.147
Subject(s) - chemistry , dipalmitoylphosphatidylcholine , bilayer , phase (matter) , aqueous solution , hexagonal phase , organic chemistry , membrane , biochemistry , phospholipid , phosphatidylcholine
The effects of diphenyltin dichloride (DPhT) and triphenyltin chloride (TPhT) on polymorphic phase behaviour of aqueous dispersions of a dipalmitoylphosphatidylcholine (DPPC) bilayer were investigated by means of 31 P NMR. It is suggested that DPhT induces interdigitated gel phase formation and TPhT induces hexagonal phase formation. The toxic activities of DPhT and TPhT seem to be connected with their ability to induce changes in the membrane structure. Copyright © 2001 John Wiley & Sons, Ltd.