Synthesis and application of bimetallic chiral [Co(salen)]‐type complexes: a new catalytic approach to synthesis of optically pure β‐blockers via kinetic resolution of epichlorohydrin | Zendy

Kawthekar Rahul B. | Zendy; Bi Wentao | Zendy; Kim GeonJoong | Zendy

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Synthesis and application of bimetallic chiral [Co(salen)]‐type complexes: a new catalytic approach to synthesis of optically pure β‐blockers via kinetic resolution of epichlorohydrin

Author(s) -

Kawthekar Rahul B.,

Bi Wentao,

Kim GeonJoong

Publication year - 2008

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.1447

Subject(s) - bimetallic strip , chemistry , epichlorohydrin , kinetic resolution , enantioselective synthesis , catalysis , combinatorial chemistry , optically active , organic chemistry , polymer chemistry

A series of bimetallic chiral [Co(salen)]‐type complexes were successfully applied for the synthesis of optically pure β‐blockers via phenolic kinetic resolution (PKR) of racemic epichlorohydrin [2‐(chloromethyl)oxirane; ( ± )ECH]. The reaction proceeded readily at room temperature and consequently provided enantiomerically enriched corresponding α‐aryloxy alcohols with excellent enantioselectivities of up to 98% ee. The PKR method described in this work is highly efficient and straightforward strategy for the synthesis of chiral building blocks. Copyright © 2008 John Wiley & Sons, Ltd.

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